Publications 2016

Coordination of signalling networks and tumorigenic properties by ABL in glioblastoma cells. F. Lamballe, S. Toscano, F. Conti, M. Arechederra, N. Baeza, D. Figarella-Branger, F. Helmbacher and F. Maina. Oncotarget. 2016 Oct 9. doi: 10.18632/oncotarget.12546.


PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF. Satish K. Tadi, Carine Tellier-Lebègue, Clément Nemoz, Pascal Drevet, Stéphane Audebert, Sunetra Roy, Katheryn Meek, Jean-Baptiste Charbonnier, and Mauro Modesti. Cell Reports (2016). DOI:10.1016/j.celrep.2016.09.026.


Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy. Ruxanda Moschoi, Véronique Imbert, Marielle Nebout, Johanna Chiche, Didier Mary, Thomas Prebet, Estelle Saland, Rémy Castellano, Laurent Pouyet, Yves Collette, Norbert Vey, Christian Chabannon, Christian Recher, Jean-Emmanuel Sarry, Damien Alcor, Jean-François Peyron, Emmanuel Griessinger. .


Personne de confiance : un partenaire dans la décision partagée. Aline Sarradon-Eck, Géraldine Capodano, Eve Bureau, Claire Julian-Reynier. Bulletin du Cancer 16-AUG-2016.

BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice. Hamouda MA, Jacquel A, Robert G, Puissant A, Richez V, Cassel R, Fenouille N, Roulland S, Gilleron J, Griessinger E, Dubois A, Bailly-Maitre B, Goncalves D, Mallavialle A, Colosetti P, Marchetti S, Amiot M, Gomez-Bougie P, Rochet N, Deckert M, Avet-Loiseau H, Hofman P, Karsenti JM, Jeandel PY, Blin-Wakkach C, Nadel B, Cluzeau T, Anderson KC, Fuzibet JG, Auberger P, Luciano F. J Exp Med. 2016 Aug 22;213(9):1705-22. doi: 10.1084/jem.20150983. Epub 2016 Jul 25.


PRICKLE1 Contributes to Cancer Cell Dissemination through Its Interaction with mTORC2. Daulat AM, Bertucci F, Audebert S, Sergé A, Finetti P, Josselin E, Castellano R, Birnbaum D, Angers S, Borg JP. Dev Cell. 2016 May 23;37(4):311-25. doi: 10.1016/j.devcel.2016.04.011. Epub 2016 May 12.


Predicting quantitative traits from genome and phenome with near perfect accuracy. Martens K, Hallin J, Warringer J, Liti G & Parts L. Nat Commun. 2016.


Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling. Egea-Jimenez AL, Gallardo R, Garcia-Pino A, Ivarsson Y, Wawrzyniak AM, Kashyap R, Loris R, Schymkowitz J, Rousseau F, Zimmermann P. Nat Commun. 2016 Jul 8.

SUMO-Dependent Relocalization of Eroded Telomeres to Nuclear Pore Complexes Controls Telomere Recombination. Churikov D, Charifi F, Eckert-Boulet N, Silva S, Simon MN, Lisby M, Géli V. Cell Rep. 2016 May 10.


Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci. Philippe C, Vargas-Landin DB, Doucet AJ, Van Essen D, Vera-Otarola J, Kuciak M, Corbin A, Nigumann P, Cristofari G. eLife, 2016, Mar 26.


Clinical effect of molecular methods in sarcoma diagnosis (GENSARC): a prospective, multicentre, observational study. Italiano A, Di Mauro I, Rapp J, Pierron G, Auger N, Alberti L, Chibon F, Escande F, Voegeli AC, Ghnassia JP, Keslair F, Laé M, Ranchère-Vince D, Terrier P, Baffert S, Coindre JM, Pedeutour F. Lancet Oncol., 2016, Mar 9.


Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells. Soucie EL, Weng Z, Geirsdóttir L, Molawi K, Maurizio J, Fenouil R, Mossadegh-Keller N, Gimenez G, VanHille L, Beniazza M, Favret J, Berruyer C, Perrin P, Hacohen N, Andrau JC, Ferrier P, Dubreuil P, Sidow A, Sieweke MH. Science. 2016 Feb.


Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer. Puvirajesinghe T, Bertucci F, Jain A, Scerbo P, Belotti E, Audebert S, Sebbagh M, Lopez M, Brech A, Finetti P, Charafe-Jauffret E, Chaffanet M, Castellano R, Restouin A, Marchetto S, Collette Y, Gonçalvès A, Macara I, Birnbaum D, Kodjabachian L, Johansen T & Borg JP. Nature communications. January 12, 2016.

Publications 2015

Barete,S., Lortholary, O., Damaj, G., Hirsch, I., Chandesris, M. O., Elie, C., Hamidou, M., Durieu, I., Suarez, F., Grosbois, B., Limal, N., Gyan, E., Larroche, C., Guillet, G., Kahn, J. E., Casassus, P., Amazzough, K., Coignard-Biehler, H., Georgin-Lavialle, S., Lhermitte, L., Fraitag, S., Canioni, D., Dubreuil, P., and Hermine, O. Long-term efficacy and safety of cladribine (2-CdA) in adult patients with mastocytosis. Blood. 2015; Aug 20;126(8):1009-16.


Bonzi,J., Bornet, O., Betzi, S., Kasper, B. T., Mahal, L. K., Mancini, S. J., Schiff, C., Sebban-Kreuzer, C., Guerlesquin, F., and Elantak, L. Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions. Nat Commun. 2015; 6:6194.


Brisson,L., Pouyet, L., N’Guessan, P., Garcia, S., Lopes, N., Warcollier, G., Iovanna, J. L., and Carrier, A. The Thymus-Specific Serine Protease TSSP/PRSS16 Is Crucial for the Antitumoral Role of CD4+ T Cells. Cell Rep. 2015; 10:39-46.


Guervilly,J., Takedachi, A., Naim, V., Scaglione, S., Chawhan, C., Lovera, Y., Despras, E., Kuraoka, I., Kannouche, P., Rosselli, F., and Gaillard, P. L. The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability. Mol Cell. 2015; 57:123-137.


Iovanna,J. Short-term contracts: Labs leak staff under French law. Nature. 2015; 518:35.


Kuhnl,A., Valk, P. J., Sanders, M. A., Ivey, A., Hills, R. K., Mills, K. I., Gale, R. E., Kaiser, M. F., Dillon, R., Joannides, M., Gilkes, A., Haferlach, T., Schnittger, S., Duprez, E., Linch, D. C., Delwel, R., Lowenberg, B., Baldus, C. D., Solomon, E., Burnett, A. K., and Grimwade, D. Down-regulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia. Blood. 2015; 125:2985-2994.


Navarro,J.M., Touzart, A., Pradel, L. C., Loosveld, M., Koubi, M., Fenouil, R., Le Noir S., Maqbool, M. A., Morgado, E., Gregoire, C., Jaeger, S., Mamessier, E., Pignon, C., Hacein-Bey-Abina, S., Malissen, B., Gut, M., Gut, I. G., Dombret, H., Macintyre, E. A., Howe, S. J., Gaspar, H. B., Thrasher, A. J., Ifrah, N., Payet-Bornet, D., Duprez, E., Andrau, J. C., Asnafi, V., and Nadel, B. Site- and allele-specific polycomb dysregulation in T-cell leukaemia. Nat Commun. 2015; 6:6094.


Qin,Z., Zhou, X., Pandey, N. R., Vecchiarelli, H. A., Stewart, C. A., Zhang, X., Lagace, D. C., Brunel, J. M., Beique, J. C., Stewart, A. F., Hill, M. N., and Chen, H. H. Chronic Stress Induces Anxiety via an Amygdalar Intracellular Cascade that Impairs Endocannabinoid Signaling. Neuron. 2015; 85:1319-1331.


Tichet,M., Prod’Homme, V., Fenouille, N., Ambrosetti, D., Mallavialle, A., Cerezo, M., Ohanna, M., Audebert, S., Rocchi, S., Giacchero, D., Boukari, F., Allegra, M., Chambard, J. C., Lacour, J. P., Michiels, J. F., Borg, J. P., Deckert, M., and Tartare-Deckert, S. Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis. Nat Commun. 2015; 6:6993.


Vincentelli,R., Luck, K., Poirson, J., Polanowska, J., Abdat, J., Blemont, M., Turchetto, J., Iv, F., Ricquier, K., Straub, M. L., Forster, A., Cassonnet, P., Borg, J. P., Jacob, Y., Masson, M., Nomine, Y., Reboul, J., Wolff, N., Charbonnier, S., and Trave, G. Quantifying domain-ligand affinities and specificities by high-throughput holdup assay. Nat Methods. 2015; Aug;12(8):787-93.


Adhoute,X., Penaranda, G., Raoul, J. L., and Bourliere, M. Reply to:  »Repeated transarterial chemoembolization: An overfitting effort? ». J Hepatol. 2015; 62:1442-1443.


Adhoute,X., Penaranda, G., Naude, S., Raoul, J. L., Perrier, H., Bayle, O., Monnet, O., Beaurain, P., Bazin, C., Pol, B., Le Folgoc, G., Castellani, P., Bronowicki, J. P., and Bourliere, M. Retreatment with TACE: the ABCR SCORE, an aid to the decision-making process. J Hepatol. 2015; 62:855-862.


Adhoute,X., Penaranda, G., Blanc, J. F., Edeline, J., Naude, S., Perrier, H., Monnet, O., Castellani, P., Oules, V., Bayle, O., Conroy, G., Benali, S., Lefolgoc, G., Pol, B., Bronowicki, J. P., Raoul, J. L., and Bourliere, M. Stratification of hepatocellular carcinoma. The prognostic score NIACE, an additional aid to the Barcelona Clinic Liver Cancer (BCLC) staging system? Multicenter study. J Hepatol. 2015; 62:S453.


Adhoute,X., Penaranda, G., Bronowicki, J. P., and Raoul, J. L. Usefulness of HKLC versus BCLC staging system in a European HCC cohort. J Hepatol. 2015; 62:492-493.


Dhedin,N., Huynh, A., Maury, S., Tabrizi, R., Beldjord, K., Asnafi, V., Thomas, X., Chevallier, P., Nguyen, S., Coiteux, V., Bourhis, J. H., Hichri, Y., Escoffre-Barbe, M., Reman, O., Graux, C., Chalandon, Y., Blaise, D., Schanz, U., Lheritier, V., Cahn, J. Y., Dombret, H., and Ifrah, N. Role of allogeneic stem cell transplantation in adult patients with Ph-negative acute lymphoblastic leukemia. Blood. 2015; 125:2486-2496.


Fizazi,K., Faivre, L., Lesaunier, F., Delva, R., Gravis, G., Rolland, F., Priou, F., Ferrero, J. M., Houede, N., Mourey, L., Theodore, C., Krakowski, I., Berdah, J. F., Baciuchka, M., Laguerre, B., Flechon, A., Ravaud, A., Cojean-Zelek, I., Oudard, S., Labourey, J. L., Chinet-Charrot, P., Legouffe, E., Lagrange, J. L., Linassier, C., Deplanque, G., Beuzeboc, P., Davin, J. L., Martin, A. L., Habibian, M., Laplanche, A., and Culine, S. Androgen deprivation therapy plus docetaxel and estramustine versus androgen deprivation therapy alone for high-risk localised prostate cancer (GETUG 12): a phase 3 randomised controlled trial. Lancet Oncology. 2015; Jul;16(7):787-94.


Forner,A., Gilabert, M., Bruix, J., and Raoul, J. L. Intermediate-stage HCC-upfront resection can be feasible. Nat Rev Clin Oncol. 2015; 12:295.


Forner,A., Gilabert, M., Bruix, J., and Raoul, J. L. Reply: Heterogeneity of intermediate-stage HCC necessitates personalized management including surgery. Nature Rev Clin Oncol. 2015; 12:10.


Hebraud,B., Magrangeas, F., Cleynen, A., Lauwers-Cances, V., Chretien, M. L., Hulin, C., Leleu, X., Yon, E., Marit, G., Karlin, L., Roussel, M., Stoppa, A. M., Belhadj, K., Voillat, L., Garderet, L., Macro, M., Caillot, D., Mohty, M., Facon, T., Moreau, P., Attal, M., Munshi, N., Corre, J., Minvielle, S., and Avet-Loiseau, H. Role of additional chromosomal changes in the prognostic value of t(4;14) and del(17p) in multiple myeloma: the IFM experience. Blood. 2015; 125:2095-2100.


Le Cesne,A., Blay, J. Y., Domont, J., Tresch-Bruneel, E., Chevreau, C., Bertucci, F., Delcambre, C., Saada-Bouzid, E., Piperno-Neumann, S., Bay, J. O., Mir, O., Ray-Coquard, I., Ryckewaert, T., Valentin, T., Isambert, N., Italiano, A., Clisant, S., and Penel, N. Interruption versus continuation of trabectedin in patients with soft-tissue sarcoma (T-DIS): a randomised phase 2 trial. Lancet Oncology. 2015; 16:312-319.


Leleu,X., Karlin, L., Macro, M., Hulin, C., Garderet, L., Roussel, M., Arnulf, B., Pegourie, B., Kolb, B., Stoppa, A. M., Brechiniac, S., Marit, G., Thielemans, B., Onraed, B., Mathiot, C., Banos, A., Lacotte, L., Tiab, M., Dib, M., Fuzibet, J. G., Petillon, M. O., Rodon, P., Wetterwald, M., Royer, B., Legros, L., Benboubker, L., Decaux, O., Escoffre-Barbe, M., Caillot, D., Fermand, J. P., Moreau, P., Attal, M., Avet-Loiseau, H., and Facon, T. Pomalidomide plus low-dose dexamethasone in multiple myeloma with deletion 17p and/or translocation (4;14): IFM 2010-02. Blood. 2015; 125:1411-1417.


Rebbeck,T.R., Mitra, N., Wan, F., Sinilnikova, O. M., Healey, S., McGuffog, L., Mazoyer, S., Chenevix-Trench, G., Easton, D. F., Antoniou, A. C., Nathanson, K. L., Laitman, Y., Kushnir, A., Paluch-Shimon, S., Berger, R., Zidan, J., Friedman, E., Ehrencrona, H., Stenmark-Askmalm, M., Einbeigi, Z., Loman, N., Harbst, K., Rantala, J., Melin, B., Huo, D., Olopade, O. I., Seldon, J., Ganz, P. A., Nussbaum, R. L., Chan, S. B., Odunsi, K., Gayther, S. A., Domchek, S. M., Arun, B. K., Lu, K. H., Mitchell, G., Karlan, B. Y., Walsh, C., Lester, J., Godwin, A. K., Pathak, H., Ross, E., Daly, M. B., Whittemore, A. S., John, E. M., Miron, A., Terry, M. B., Chung, W. K., Goldgar, D. E., Buys, S. S., Janavicius, R., Tihomirova, L., Tung, N., Dorfling, C. M., van Rensburg, E. J., Steele, L., Neuhausen, S. L., Ding, Y. C., Ejlertsen, B., Gerdes, A. M., Hansen, T., Cajal, T., Osorio, A., Benitez, J., Godino, J., Tejada, M. I., Duran, M., Weitzel, J. N., Bobolis, K. A., Sand, S. R., Fontaine, A., Savarese, A., Pasini, B., Peissel, B., Bonanni, B., Zaffaroni, D., Vignolo-Lutati, F., Scuvera, G., Giannini, G., Bernard, L., Genuardi, M., Radice, P., Dolcetti, R., Manoukian, S., Pensotti, V., Gismondi, V., Yannoukakos, D., Fostira, F., Garber, J., Torres, D., Rashid, M. U., Hamann, U., Peock, S., Frost, D., Platte, R., Evans, D. G., Eeles, R., Davidson, R., Eccles, D., Cole, T., Cook, J., Brewer, C., Hodgson, S., Morrison, P. J., Walker, L., Porteous, M. E., Kennedy, M. J., Izatt, L., Adlard, J., Donaldson, A., Ellis, S., Sharma, P., Schmutzler, R. K., Wappenschmidt, B., Becker, A., Rhiem, K., Hahnen, E., Engel, C., Meindl, A., Engert, S., Ditsch, N., Arnold, N., Plendl, H. J., Mundhenke, C., Niederacher, D., Fleisch, M., Sutter, C., Bartram, C. R., Dikow, N., Wang-Gohrke, S., Gadzicki, D., Steinemann, D., Kast, K., Beer, M., Varon-Mateeva, R., Gehrig, A., Weber, B. H., Stoppa-Lyonnet, D., Sinilnikova, O. M., Mazoyer, S., Houdayer, C., Belotti, M., Gauthier-Villars, M., Damiola, F., Boutry-Kryza, N., Lasset, C., Sobol, H., Peyrat, J. P., Muller, D., Fricker, J. P., Collonge-Rame, M. A., Mortemousque, I., Nogues, C., Rouleau, E., Isaacs, C., De Paepe A., Poppe, B., Claes, K., De Leeneer K., Piedmonte, M., Rodriguez, G., Wakely, K., Boggess, J., Blank, S. V., Basil, J., Azodi, M., Phillips, K. A., Caldes, T., de la Hoya, M., Romero, A., Nevanlinna, H., Aittomaki, K., van der Hout, A. H., Hogervorst, F. B., Verhoef, S., Collee, J. M., Seynaeve, C., Oosterwijk, J. C., Gille, J. J., Wijnen, J. T., Garcia, E. B., Kets, C. M., Ausems, M. G., Aalfs, C. M., Devilee, P., Mensenkamp, A. R., Kwong, A., Olah, E., Papp, J., Diez, O., Lazaro, C., Darder, E., Blanco, I., Salinas, M., Jakubowska, A., Lubinski, J., Gronwald, J., Jaworska-Bieniek, K., Durda, K., Sukiennicki, G., Huzarski, T., Byrski, T., Cybulski, C., Toloczko-Grabarek, A., Zlowocka-Perlowska, E., Menkiszak, J., Arason, A., Barkardottir, R. B., Simard, J., Laframboise, R., Montagna, M., Agata, S., Alducci, E., Peixoto, A., Teixeira, M. R., Spurdle, A. B., Lee, M. H., Park, S. K., Kim, S. W., Friebel, T. M., Couch, F. J., Lindor, N. M., Pankratz, V. S., Guidugli, L., Wang, X., Tischkowitz, M., Foretova, L., Vijai, J., Offit, K., Robson, M., Rau-Murthy, R., Kauff, N., Fink-Retter, A., Singer, C. F., Rappaport, C., Gschwantler-Kaulich, D., Pfeiler, G., Tea, M. K., Berger, A., Greene, M. H., Mai, P. L., Imyanitov, E. N., Toland, A. E., Senter, L., Bojesen, A., Pedersen, I. S., Skytte, A. B., Sunde, L., Thomassen, M., Moeller, S. T., Kruse, T. A., Jensen, U. B., Caligo, M. A., Aretini, P., and Teo, S. H. Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. JAMA. 2015; 313:1347-1361.


Roberto,A., Castagna, L., Zanon, V., Bramanti, S., Crocchiolo, R., McLaren, J. E., Gandolfi, S., Tentorio, P., Sarina, B., Timofeeva, I., Santoro, A., Carlo-Stella, C., Bruno, B., Carniti, C., Corradini, P., Gostick, E., Ladell, K., Price, D. A., Roederer, M., Mavilio, D., and Lugli, E. Role of naive-derived T memory stem cells in T cell reconstitution following allogeneic transplantation. Blood. 2015; 125:2855-2865.


Qurrat Ul Ain, Antoniya Aleksandrova, Florian D. Roessler and Pedro J. Ballester. Machine-learning scoring functions to improve structure-based binding affinity prediction and virtual screening. Computational Molecular Science. Article first published online: 28 AUG 2015. DOI: 10.1002/wcms.1225.


C Oudin, P Auquier, Y Bertrand, A Contet, J Kanold, N Sirvent, S Thouvenin, M-D Tabone, P Lutz, S Ducassou, D Plantaz, J-H Dalle, V Gandemer, S Beliard, J Berbis, C Vercasson, V Barlogis, A Baruchel, G Leverger and G Michel. Bone Marrow Transplantation , (20 July 2015) | doi:10.1038/bmt.2015.167.


Wei T, Chen C, Liu J, Liu C, Posocco P, Liu X, Cheng Q, Huo S, Liang Z, Fermeglia M, Pricl S, Liang XJ, Rocchi P, Peng L. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):2978-83. doi: 10.1073/pnas.1418494112. Epub 2015 Feb 23.