This topic will contribute to the achievement of the mission’s goal through a better understanding of the impact of risk factors and health determinants on the development and progression of cancer (including metastasis). The focus should be on poorly understood cancers and cancer subtypes, including in children and adolescents. To that end, proposals under this topic should aim for delivering results that are directed, tailored towards and contributing to all of the following expected outcomes.
- Researchers and health professionals will understand which risk factors and determinants spur the development and progression of cancer and how. This forms the basis for the design and optimisation of prevention, screening and early detection interventions for poorly understood cancers and cancer subtypes, including in children and adolescents.
- Researchers and innovators from different disciplines and sectors will support the development of the UNCAN.eu platform by producing, integrating and correlating comprehensive data from multiple sources (ensuring accessibility and re-usability of data, models and tools created).
Despite important progress, overall understanding of cancer remains incomplete, for both common and rare cancers and the growing number of cancer subtypes, including in children and adolescents. This requires a new dimension and level of investment in innovative research, including high-potential, potentially disruptive and high-risk projects. There is a need to better understand which risk factors and determinants affect the development and progression of cancer and how.