Publications de notre communauté

En 2023

• Combining the antianginal drug perhexiline with chemotherapy induces complete pancreatic cancer regression in vivo

• From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia

• Pancreatic ductal adenocarcinoma ubiquitination profiling reveals specific prognostic and theranostic markers

• SK2 channels set a signalling hub bolstering CAF-triggered tumourigenic processes in pancreatic cancer

• Tracing founder mutations in circulating and tissue-resident follicular lymphoma precursors

• Disruption of lineage integrity as a precursor to breast tumor initiation

• Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein–Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach

• A Transcriptomic-Based Tool to Predict Gemcitabine Sensitivity in Advanced Pancreatic Adenocarcinoma

Yifan Jiang et al. – CINaM, CRCM, AMU, Inserm, CNRS, Équipe labellisée Ligue Contre le Cancer, Marseille

• Dendrimer nanosystems for adaptive tumor-assisted drug delivery via extracellular vesicle hijacking

En 2022…

Patrick Brest et al. – IRCAN, UCA, CAL, CNRS, Inserm, Nice

• Host genetic variability and determinants of severe COVID-19

Rayane Hedna et al. – INP, AMU, CNRS, Marseille

• Tau Protein as Therapeutic Target for Cancer? Focus on Glioblastoma

Benjamin Bian et al. – IRCAN, UCA, CAL, Inserm, CNRS, Nice

• Coupling live-cell imaging and in situ isolation of the same single cell to profile the transient states of predicted drug-tolerant cells

Ling Peng et al. – CINaM, AMU, CNRS, Équipe labellisée Ligue Contre le Cancer, Marseille

• Small Activating RNA Modulation of the G Protein-Coupled Receptor for Cancer Treatment

Pierre Bourdely et al. – IPMC, UCA, CNRS, Valbonne

• Autofluorescence identifies highly phagocytic tissue-resident macrophages in mouse and human skin and cutaneous squamous cell carcinoma

Pierre-Louis Bernard et al. – CRCM, IPC, Inserm, CNRS, Marseille

• Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity

Raphael Rapetti-Mauss et al. – iBV, UCA, CNRS, Inserm, Nice

• SK2 channels set a signalling hub bolstering CAF-triggered tumourigenic processes in pancreatic cancer

Avais M Daulat et al. – CRCM, IPC, CNRS, Inserm, Marseille

• The serine/threonine kinase MINK1 directly regulates the function of promigratory proteins

Adriana Martinez-Turcos et al. – C3M, UCA, Inserm, Nice

• IRE1α overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune response

Manuel Grima-Reyes et al. – C3M, UCA, Inserm, Nice

• Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression

Renaud Schiappa et al. – CAL, UCA, Nice

• RUBY: Natural Language Processing of French Electronic Medical Records for Breast Cancer Research

Kevin Atsou et al. – UCA, Inria, CNRS, LJAD, Nice

• Analysis of the Equilibrium Phase in Immune-Controlled Tumors Provides Hints for Designing Better Strategies for Cancer Treatment

Kendall Carrasco et al. – CRCM, IPC, AMU, CNRS, Inserm, Marseille

• CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation

Marius Ilié et al. – IRCAN, UCA, CHU de Nice, CAL, FHU OncoAge – Nice

• Deep Learning Facilitates Distinguishing Histologic Subtypes of Pulmonary Neuroendocrine Tumors on Digital Whole-Slide Images

Christopher Rovera et al. – C3M, UCA, Inserm, CNRS, Equipe labellisée Ligue Contre le Cancer – Nice

• Secretion of interleukin-1 by dedifferentiated melanoma cells inhibits JAK1-STAT3-driven actomyosin contractility of lymph node fibroblastic reticular cells

Serena Diazzi et al. – C3M, IPMC, UCA, Inserm, CNRS, Equipe labellisée Ligue Contre le Cancer – Nice

• Blockade of the pro-fibrotic reaction mediated by the miR-143/-145 cluster enhances the responses to targeted therapy in melanoma

Véronique M Braud et al. – IPMC, UCA, CNRS, Valbonne

• LLT1-CD161 Interaction in Cancer: Promises and Challenges

Violette Azzoni et al. – CRCM, IPC, AMU, CNRS, Inserm, Epithelial Stem Cells and Cancer Lab, Equipe labellisée Ligue Contre le Cancer – Marseille

• BMI1 nuclear location is critical for RAD51-dependent response to replication stress and drives chemoresistance in breast cancer stem cells

Chantal L Duurland et al. – Department of Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands

• CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors

En 2021…

Ilona Berestjuk et al. – C3M, UCA, Inserm, Equipe labellisée Ligue Contre le Cancer, Team MicroCan – Nice

• Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma

Sylvain Garciaz et al. – CRCM, IPC, AMU, Inserm, CNRS – Marseille

• Pharmacological reduction of mitochondrial iron triggers a non-canonical BAX/BAK dependent cell death

Friederike Knipping et al. – Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA

• Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing

Aline Sarrandon-Eck et al. – AMU, Inserm, IRD, SESSTIM, ISSPAM, IPC, CanBios U1252 – Marseille

• PALLIATIF : Un mot saturé de sens

Sara Lee et al. – CRCM, IPC, AMU, Inserm, CNRS – Marseille

• UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival

Anaïs Hagège et al. – IRCAN, UCA, CAL, CNRS, Inserm- Nice

• The Polo-like kinase 1 inhibitor onvansertib represents a relevant treatment for head and neck squamous cell carcinoma resistant to cisplatin and radiotherapy

Olivier Castellanet & Fahmida Ahmad et al. – IBDM, AMU, CNRS – Marseille

• BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators

Juan Liu et al. – CINaM, AMU, CNRS – Marseille

• Dendrimeric nanosystem consistently circumvents heterogeneous drug response and resistance in pancreatic cancer

Karine Jacquet, Olivia Vidal-Cruchez & Patrick Brest (IRCAN, UCA, CAL, CNRS, Inserm- Nice), Bernard Mari (IPMC, UCA, CNRS – Sophia Antipolis), Georges Vassaux (IPMC, UCA, Inserm, CNRS – Sophia Antipolis) et al.

• New technologies for improved relevance in miRNA research

Oleksandr Grytsai et al. – UCA, ICN, CNRS – Nice / CRUK Manchester Institute

• Biguanides drugs: Past success stories and promising future for drug discovery

Noushin Mossadegh-Keller et al. – CIML, AMU, CNRS, Inserm- Marseille

• Human B Lymphomas Reveal Their Secrets Through Genetic Mouse Models

Mohamed Belhocine et al. – TAGC, AMU, Inserm- Marseille

• Dynamic of broad H3K4me3 domains uncover an epigenetic switch between cell identity and cancer-related genes.

Anne-Sophie Chrétien et al. – CRCM, IPC, AMU, CNRS, Inserm- Marseille

• High-dimensional mass cytometry analysis of NK cell alterations in AML identifies a subgroup with adverse clinical outcome

Giulia Lucibello et al. – UCA, IRCAN, CAL, CNRS, Inserm- Nice

• PD-L1 regulation revisited: impact on immunotherapeutic strategies

Louciné Mitoyan et al. – CRCM, IPC, AMU, CNRS, Inserm- Marseille

• A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration

Julie Agopian et al. – CRCM, IPC, Inserm, CNRS – Marseille

• GlcNAc is a mast-cell chromatin-remodeling oncometabolite that promotes systemic mastocytosis aggressiveness

Roxane Elaldi et al. – IPMC, IUFC, UCA, CNRS – Valbonne

• High Dimensional Imaging Mass Cytometry Panel to Visualize the Tumor Immune Microenvironment Contexture

Carmelo Luci et al. – IPMC, UCA CNRS – Valbonne

• Cutaneous Squamous Cell Carcinoma Development is Associated with a Temporal Infiltration of ILC1 and NK Cells with Immune Dysfunctions

Alexandre Chuyen et al. – IBDM, AMU, CNRS – Marseille

• The Scf/Kit pathway implements self-organized epithelial patterning

Le He et al. – CIML, AMU, CNRS, Inserm- Marseille

• ARHGAP45 controls naïve T‐ and B‐ cell entry into lymph nodes and T‐cell progenitor thymus seeding

Philipp O. Tsvetkov et al. – INP, AMU, CNRS – Marseille

• An AI-Powered Blood Test to Detect Cancer Using NanoDSF

Tracy Rabilloud, Delphine Potier et al. – CIML, AMU, CNRS, Inserm- Marseille

• Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy

Marius Ilié et al. – IRCAN, CHU de Nice, UCA, CNRS, Inserm- Nice

• Prospective multi-center validation of the detection of ALK rearrangements of circulating tumor cells for non-invasive longitudinal management of patients with advanced non-small cell lung cancer

Laetitia Douguet & Serena Janho dit Hreich et al. – IRCAN, UCA, Inserm, CNRS – Nice

• A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy

Stéphane Fattori et al. – CRCM, IPC, AMU, CNRS, Inserm- Marseille

• Quantification of Immune Variables from Liquid Biopsy in Breast Cancer Patients Links Vδ2 ⁺ γδ T Cell Alterations with Lymph Node Invasion

Alejandra Gutierrez-Guerrero et al. – CIRI, UCBL, ENS, Inserm, CNRS – Lyon

• Baboon Envelope Pseudotyped “Nanoblades” Carrying Cas9/gRNA Complexes Allow Efficient Genome Editing in Human T, B, and CD34⁺ Cells and Knock-in of AAV6-Encoded Donor DNA in CD34⁺ Cells

Jiaxuan Chen et al. – CINaM, AMU, CNRS – Marseille

• Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells

Emilie Jaune et al. – C3M, UCA, Inserm- Nice

• Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies

En 2020…

Fabienne Lamballe et al. – IBDM, AMU, CNRS – Marseille

• Modeling Heterogeneity of Triple‐Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance

Maria Gonçalves-Maia et al. – IRCAN, UCA, INSERM, CNRS – Nice

• NK Cell and Fibroblast-Mediated Regulation of Skin Squamous Cell Carcinoma Invasion by CLEC2A Is Compromised in Xeroderma Pigmentosum

Kevin Atsou et al. – UCA, INRIA, CNRS – Nice

• A size and space structured model describing interactions of tumor cells with immune cells reveals cancer persistent equilibrium states in tumorigenesis

Ling Ding et al. – CINaM, AMU, CNRS – Marseille

• An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile

Rafael J. Argüello et al. – CIML, AMU, CNRS, INSERM – Marseille

• SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution

Adeline Crinier et al. – CIML, AP-HM, AMU, CNRS, INSERM – Marseille

• Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia

Rawand Masoud et al. – CRCM, AMU, IPC, CNRS, INSERM – Marseille

• Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer

Béatrice Cambien et al. – UCA, CEA, TIRO – Nice

• Identification of oncolytic vaccinia restriction factors in canine high-grade mammary tumor cells using single-cell transcriptomics

Maria Arechederra et al. – IBDM, AMU, CNRS – Marseille

• ADAMTSL5 is an epigenetically activated gene underlying tumorigenesis and drug resistance in hepatocellular carcinoma

Jonathan Benzaquen et al. – IRCAN, UCA, CNRS INSERM – Nice

• P2RX7B is a new theranostic marker for lung adenocarcinoma patients

Sokchea Khou et al. – IPMC, UCA, CNRS – Valbonne

• Tumor-Associated Neutrophils Dampen Adaptive Immunity and Promote Cutaneous Squamous Cell Carcinoma Development

Ellen Van Obberghen Schilling – iBV, UCA, INSERM, CNRS – Nice

• Tenascin-C orchestrates an immuno-suppressive microenvironment in oral squamous cell carcinoma

Nicolas A. Fraunhoffer et al. – CRCM, IPC, AMU, INSERM, CNRS – Marseille

• Evidencing a pancreatic ductal adenocarcinoma subpopulation sensitive to the proteasome inhibitor Carfilzomib

Wenjun Lan et al. – CRCM, IPC, AMU, INSERM, CNRS – Marseille

• ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

Ling Ding et al. – CINaM, AMU, CNRS – Marseille

• Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study

Nelson Dusetti et al. – CRCM, IPC, AMU, INSERM, CNRS – Marseille

• Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

Natalia Juiz et al. – CRCM, IPC, AMU, INSERM, CNRS – Marseille

• Basal‐like and classical cells coexist in pancreatic cancer revealed by single‐cell analysis on biopsy‐derived pancreatic cancer organoids from the classical subtype